[Effect of chloroform and ether narcosis on the activity of basic carboxypeptidases in the hypothalamic-pituitary-adrenal axis in rats].

Abstract

It is discovered that chloroform narcosis does not influence on carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity in the rats hypothalamic-pituitary-adrenal axis. Ether narcosis provokes an increase of PMSF-inhibited carboxypeptidase activity in the pituitary body approximately in 8 times and carboxypeptidase H activity in hypothalamus by 29 percents in comparison with the intact animals. It is supposed that at research neuropeptides and their metabolism enzymes and especially the answer to a stress chloroform narcosis would be the better anaesthesia method than ether narcosis.

• Authors: A N Vernigora, M T Gengin, E S Mukhina, O E Mikhaĭlova
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2002 May-Jun Vol. 74 Issue 3 Pg. 124-5 Ukraine
• Vernacular Title: Vliianie khloroformnogo i éfirnogo narkoza na aktivnost' osnovnykh karboksipeptidaz v gipotalamo-gipofizarno-nadpochechnikovoĭ sisteme krys.
• PMID: 12916250 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anesthetics, Inhalation
• Enzyme Inhibitors
• Ether
• Phenylmethylsulfonyl Fluoride
• Chloroform
• Carboxypeptidases
• Carboxypeptidase H

Topics

• Anesthetics, Inhalation (pharmacology)
• Animals
• Carboxypeptidase H (metabolism)
• Carboxypeptidases (metabolism)
• Chloroform (pharmacology)
• Enzyme Inhibitors (pharmacology)
• Ether (pharmacology)
• Hypothalamo-Hypophyseal System (drug effects, enzymology)
• Phenylmethylsulfonyl Fluoride (pharmacology)
• Pituitary-Adrenal System (drug effects, enzymology)
• Rats