Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice.

Abstract	We investigated the effects of rat cocaine- and amphetamine-regulated transcript CART (55-102) after i.c.v. administration in mouse models of acute and persistent pain. CART was not active in the tail-flick or PPQ tests. It increased the latency to paw licking in the hot-plate test but only at doses that impaired motor function. CART produces antinociception in the formalin test in both phases. Our results suggest that CART is involved in supraspinal pain transmission.
Authors	M Imad Damaj, Billy R Martin, Michael J Kuhar
Journal	Brain research (Brain Res) Vol. 983 Issue 1-2 Pg. 233-6 (Sep 05 2003) ISSN: 0006-8993 [Print] Netherlands
PMID	12914986 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Analgesics Nerve Tissue Proteins Peptide Fragments cocaine- and amphetamine-regulated transcript protein (55-102) Formaldehyde
Topics	Analgesics Animals Dose-Response Relationship, Drug Formaldehyde Hot Temperature Injections, Intraventricular Mice Mice, Inbred ICR Nerve Tissue Proteins Pain Measurement (drug effects) Peptide Fragments (administration & dosage, pharmacology) Postural Balance (drug effects) Rats Reaction Time (drug effects)

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