Abstract | BACKGROUND: Whether ileal absorption of bile acid is up or downregulated in chronic cholestasis is still debated, and most evidence has come from animal studies. AIMS: PATIENTS: We studied 14 PBC patients before and during (n=11) UDCA administration, 14 healthy control subjects, and 14 Crohn's disease patients (as disease controls). METHODS: We used cholescintigraphy to measure retention in the enterohepatic circulation over five successive days of the bile acid analogue (75)Se-homocholic acid- taurine ((75) SeHCAT) as an index of ileal bile acid absorption. Results were expressed as (75) SeHCAT fractional turnover rate (FTR) and t(1/2)12. RESULTS: (75) SeHCAT FTR was 0.19 (0.11)/day, 0.34 (0.11)/day (p<0.001), and 0.83 (0.32)/day in PBC patients, healthy controls (p<0.0001), and Crohn's patients (p<0.001), respectively, which increased to 0.36 (0.16)/day in PBC patients during UDCA treatment (p<0.005). (75) SeHCAT t(1/2)12 was 4.8 (2.1) days in PBC patients, 2.2 (0.5) days (p<0.001) in healthy controls, and 1.0 (0.5) days (p<0.001) in Crohn's disease patients. (75) SeHCAT t(1/2)12 decreased to 2.2 (0.93) days (p< 0.001) in PBC patients during UDCA treatment. CONCLUSIONS: Our results support the concept that ileal bile acid absorption is upregulated in PBC patients, and that this effect may contribute towards damaging the cholestatic liver. This upregulation of bile acid absorption is abolished by UDCA.
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Authors | A Lanzini, M G De Tavonatti, B Panarotto, S Scalia, A Mora, F Benini, O Baisini, F Lanzarotto |
Journal | Gut
(Gut)
Vol. 52
Issue 9
Pg. 1371-5
(Sep 2003)
ISSN: 0017-5749 [Print] England |
PMID | 12912872
(Publication Type: Journal Article)
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Chemical References |
- Bile Acids and Salts
- Cholagogues and Choleretics
- Selenium Radioisotopes
- Taurine
- Taurocholic Acid
- Ursodeoxycholic Acid
- 23-seleno-25-homotaurocholic acid
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Topics |
- Adult
- Aged
- Bile Acids and Salts
(metabolism)
- Cholagogues and Choleretics
(administration & dosage)
- Female
- Humans
- Ileum
(metabolism)
- Intestinal Absorption
(drug effects)
- Liver Cirrhosis, Biliary
(drug therapy, metabolism)
- Middle Aged
- Selenium Radioisotopes
(metabolism)
- Taurine
(metabolism)
- Taurocholic Acid
(analogs & derivatives, metabolism)
- Ursodeoxycholic Acid
(administration & dosage)
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