Comparative study on two kidney graft rinsing and preservation solutions in terms of the post-transplantation risk of delayed graft function and cost.

Abstract

OBJECTIVE:

To determine whether Belzer solution (Viaspan, Bristol-Myers Squibb, Brussels, Belgium), which is more expensive than Eurocollins solution, was better at preventing delayed graft function (DGF) and whether it was cost-effective as it could potentially reduce post-transplantation complications.

METHOD:

The risk of occurrence of complications associated with the use of these two rinsing and preserving solutions was estimated from a survey of 106 patients undergoing renal transplantation between 1 January 1993 and 31 March 1998. Both efficacy and adverse outcomes were recorded along with the costs directly associated with the transplantation procedure in the hospital setting: hospitalization, rinsing and preserving solutions, medical and technical interventions and diagnostic tests.

RESULTS:

For the 45 kidney grafts rinsed and preserved with Eurocollins (strategy S1: n1 = 45) the cost/graft was estimated at 40 euros. With Viaspan (strategy S2: n2 = 61) the corresponding cost/graft was 424 euros. Logistic regression analysis showed that Viaspan was better than Eurocollins solution (ebeta = 0.437; P = 0.05) in preventing DGF. Overall, S2 was less expensive than S1, from the hospital's perspective. The mean difference per patient was 278 euros, which amounts to a saving of 2% of the total cost per renal transplantation. For rinsing and preserving kidney grafts Belzer solution is therefore preferable to Eurocollins solution.

• Authors: J Vincentelli, A Luccioni, B Devictor, B Dussol, E Lechevallier, P Bertault-Peres, C Coulange, Y Berland, C Penot Ragon
• Journal: Journal of clinical pharmacy and therapeutics (J Clin Pharm Ther) Vol. 28 Issue 4 Pg. 273-7 (Aug 2003) ISSN: 0269-4727 [Print] England
• PMID: 12911678 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Euro-Collins' solution
• Hypertonic Solutions
• Insulin
• Organ Preservation Solutions
• University of Wisconsin-lactobionate solution
• Allopurinol
• Glutathione
• Adenosine
• Raffinose

Topics

• Adenosine (adverse effects, economics)
• Allopurinol (adverse effects, economics)
• Cost Savings
• Cost-Benefit Analysis
• Glutathione (adverse effects, economics)
• Graft Survival
• Humans
• Hypertonic Solutions (adverse effects, economics)
• Insulin (adverse effects, economics)
• Kidney
• Kidney Transplantation (adverse effects, economics)
• Kidney Tubular Necrosis, Acute (etiology, prevention & control)
• Organ Preservation (methods)
• Organ Preservation Solutions (adverse effects, economics)
• Raffinose (adverse effects, economics)
• Retrospective Studies