Abstract | OBJECTIVE: The aim was to correlate the relative abilities of amiodarone, lignocaine, and penticainide in suppressing ventricular tachyarrhythmias in response to coronary artery occlusion with their relative abilities to prolong ventricular functional refractory periods and to reduce intraventricular conduction velocities in anaesthetised open chest rats. METHODS: Functional refractory period was measured with a paired electrical stimulation technique. Intraventricular conduction velocity was monitored using the QRS duration of the ECG. RESULTS: CONCLUSIONS: Among these three drugs an increase in functional refractory period appears to be antiarrhythmic. In contrast, widening of the QRS complex without a corresponding increase in functional refractory period, as produced by penticainide, appears to counteract the antiarrhythmic effect.
|
Authors | J Y Li, B J Northover |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 26
Issue 11
Pg. 1116-20
(Nov 1992)
ISSN: 0008-6363 [Print] England |
PMID | 1291090
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Arrhythmia Agents
- Propylamines
- Pyridines
- propisomide
- Lidocaine
- Amiodarone
|
Topics |
- Amiodarone
(pharmacology)
- Animals
- Anti-Arrhythmia Agents
(pharmacology)
- Coronary Vessels
(physiology)
- Dose-Response Relationship, Drug
- Electrocardiography
- Heart Rate
(drug effects)
- Lidocaine
(pharmacology)
- Male
- Propylamines
(pharmacology)
- Pyridines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reaction Time
|