[Effect of ginsenoside Rg3 on the progression of orthotopically xenotransplanted human breast cancer in nude mice and its mechanism].

Abstract

OBJECTIVE:

To explore the inhibiting effect of ginsenoside Rg3 on the growth and angiogenesis of orthotopically xenotransplanted human breast infiltrating duct carcinoma in nude mice.

METHODS:

A total of 15 female nude mice having received xenotransplanted human breast infiltrating duct carcinoma were randomly divided into 3 groups. Ginsenoside Rg3 (5 mg/kg, qd), cyclophosphamid (26 mg/kg, qod) and control solution (0.5% sodium carboxymethyl cellulose, qd) were given to each group by gas-trogavage in 0.5 ml volume for 56 days. Breast cancer masses were collected for light microscope observation. The intra-tumoral microvessel density (MVD) and the expression of vascular endothelial growth factor(VEGF) were examined by immunohis-tochemical staining.

RESULTS:

The tumor weight of CTX group was significantly lower than that of control group (P < 0.05), and the comparison between those of Rg3 group and control group was nearly reaching significant level. The MVD and VEGF of Rg3 group by immunohistochemical staining were significantly lower than those of control group (P < 0.05).

CONCLUSION:

Rg3 could inhibit the growth and angiogenesis of xenotransplanted human breast infiltrating duct carcinoma in nude mice.

• Authors: Dafu Chen, Yangbing Zhao, Shaohuai Bai, Zongdao Shi, Jie Zhang
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 34 Issue 3 Pg. 546-8 (Jul 2003) ISSN: 1672-173X [Print] China
• PMID: 12910717 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents, Phytogenic
• Ginsenosides
• Vascular Endothelial Growth Factor A
• ginsenoside Rg3

Topics

• Angiogenesis Inhibitors (pharmacology)
• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Breast Neoplasms (pathology)
• Carcinoma, Ductal, Breast (pathology)
• Female
• Ginsenosides (pharmacology)
• Humans
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Neoplasm Transplantation
• Random Allocation
• Vascular Endothelial Growth Factor A (metabolism)