[The identification of the immunodominant gliadin epitope].

Abstract

Recent efforts have piri-pointed a relevant sequence on gliadin, that may act as the immunodominant epitope in celiac disease. Independent reports from several leading laboratories identify a 33 amino acid segment spanning through residues 57-89, and excessively rich in proline and glutamine, as the putative epitope. A glutamine residue in position 65 is the site of deamidation by transglutaminase, promoting its recognition by DQ2-HLA. In addition, another gluten protein, glutenin, may be relevant to the pathogenesis in celiac disease.

• Authors: B Sela
• Journal: Harefuah (Harefuah) Vol. 142 Issue 7 Pg. 554-7, 564 (Jul 2003) ISSN: 0017-7768 [Print] Israel
• PMID: 12908394 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Epitopes
• HLA-DQ Antigens
• HLA-DQ2 antigen
• Peptide Fragments
• Glutamine
• Gliadin
• Proline

Topics

• Amino Acid Sequence
• Celiac Disease (immunology)
• Epitopes (chemistry)
• Gliadin (immunology)
• Glutamine
• HLA-DQ Antigens (immunology)
• Humans
• Molecular Sequence Data
• Peptide Fragments (chemistry, immunology)
• Proline