[A comparative study between the efficacy of pentamidine isothionate given in three doses for one week and N-methil-glucamine in a dose of 20mgSbV/day for 20 days to treat cutaneous leishmaniasis].

Seventy-nine patients with cutaneous leishmaniasis were included in this study. The experimental group (n = 38) was treated with pentamidine isothionate in a dose of 4mg/kg/day on alternate days, for one week. The control group (n = 41) was treated with N-methylglucamine in a dose of 20mgSbV/kg/day for 20 days. Twenty-one isolates were identified using monoclonal antibody technique. We characterized Leishmania (Viannia) braziliensis, most frequently. There was a cure rate of 71.05% of the patients in the experimental group and 73.17% in the control group (p = 0.47). We found a statistical significance regarding frequency of ECG alterations between the experimental and control group (p<0.05). In our study pentamidine was as effective as antimonial for the treatment of american cutaneous leishmaniasis. It proved to be a safer drug considering heart toxicity. Moreover, it requires less time to complete the treatment.
AuthorsCarmen Déa Ribeiro de Paula, João Herman Duarte Sampaio, Danielle Rizzo Cardoso, Raimunda Nonata Ribeiro Sampaio
JournalRevista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) 2003 May-Jun Vol. 36 Issue 3 Pg. 365-71 ISSN: 0037-8682 [Print] Brazil
Vernacular TitleEstudo comparativo da efic cia de isotionato de pentamidina administrada em tr s doses durante uma semana e de N-metil-glucamina 20mgSbV/kg/dia durante 20 dias para o tratamento da forma cut nea da leishmaniose tegumentar americana.
PMID12908038 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Antiprotozoal Agents
  • Organometallic Compounds
  • Pentamidine
  • Meglumine
  • meglumine antimoniate
  • Adult
  • Animals
  • Antiprotozoal Agents (administration & dosage, adverse effects, economics)
  • Electrocardiography
  • Follow-Up Studies
  • Humans
  • Leishmaniasis, Cutaneous (drug therapy)
  • Meglumine (administration & dosage, adverse effects, economics)
  • Organometallic Compounds (administration & dosage, adverse effects, economics)
  • Pentamidine (administration & dosage, adverse effects, economics)
  • Prospective Studies

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