Paroxetine: new indication. In social phobia: minimal assessment.

Abstract

Social phobia is generally defined as an intense and persistent fear of one or several social situations, with important repercussions for occupational activity or social life. Cognitive psychotherapy and antidepressants have partial efficacy. There is no reference drug therapy. In France, paroxetine is the first drug to be granted a licence for patients with social phobia. Clinical evaluation consists of data from four placebo-controlled trials lasting only 12 to 24 weeks. Treatment with paroxetine was associated with a significant improvement in standard social-phobia scores, although most patients remained symptomatic. Paroxetine is the best assessed selective serotonin reuptake inhibitor in this setting. However, long-term data are lacking, and the disorder is chronic. Paroxetine has not been compared with cognitive therapy. About one-third of patients in clinical trials stopped taking paroxetine, mainly because of adverse events. Gastrointestinal upset, sleep disturbance and ejaculatory problems are frequent. Paroxetine also has the potential to interact with other drugs. In practice, paroxetine may help some patients, provided they are aware of its limitations. The long-term effects of paroxetine in this setting remain unknown.

• Journal: Prescrire international (Prescrire Int) Vol. 12 Issue 66 Pg. 137-9 (Aug 2003) ISSN: 1167-7422 [Print] France
• PMID: 12906023 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Serotonin Uptake Inhibitors
• Paroxetine

Topics

• Clinical Trials as Topic
• Drug Approval
• Drug Evaluation
• France
• Humans
• Paroxetine (adverse effects, therapeutic use)
• Phobic Disorders (drug therapy)
• Selective Serotonin Reuptake Inhibitors (adverse effects, therapeutic use)
• Treatment Outcome