Esophageal actinomycosis after allogeneic peripheral blood stem cell transplantation for extranodal natural killer/T cell lymphoma, nasal type.

Abstract

We report a 19-year-old man with extranodal natural killer (NK)/T cell lymphoma, nasal type treated by allogeneic peripheral blood stem cell transplantation (allo-PBSCT). His lymphoma was chemoresistant, and disseminated during local radiotherapy. The patient received allo-PBSCT from his HLA-1 locus mismatched sister using busulfan (BU), cyclophosphamide (CY) and VP-16 as the conditioning regimen. His course was complicated by esophageal actinomycosis 9 months after transplantation, which resulted in the rupture of the right common carotid artery. These observations suggest that actinomycosis should be monitored carefully after transplantation in patients who have received local radiation therapy before the procedure.

• Authors: T Yagi, H Fujino, M Hirai, T Inoue, M Sako, H Teshima, S Fujii, M Hino
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 32 Issue 4 Pg. 451-3 (Aug 2003) ISSN: 0268-3369 [Print] England
• PMID: 12900786 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Etoposide
• Cyclophosphamide
• Busulfan

Topics

• Actinomycosis (etiology, pathology)
• Adult
• Busulfan (pharmacology)
• Cyclophosphamide (pharmacology)
• Esophageal Diseases (pathology)
• Etoposide (pharmacology)
• Humans
• Immunosuppressive Agents (pharmacology)
• Killer Cells, Natural (cytology)
• Lymphoma, T-Cell (therapy)
• Male
• Peripheral Blood Stem Cell Transplantation (adverse effects)
• Time Factors
• Transplantation Conditioning
• Transplantation, Homologous (adverse effects, pathology)