The role of hysterectomy in the therapy of gestational trophoblastic tumor.

Abstract

OBJECTIVE:

To evaluate the role of hysterectomy for patients with gestational trophoblastic tumor.

METHODS:

We retrospectively analyzed 68 cases of gestational trophoblastic neoplasia treated by hysterectomy from 1985 to approximately 1997 at PUMC hospital. Thirty-eight cases were diagnosed of choriocarcinoma and 30 were invasive mole.

RESULTS:

Twenty-three elder patients who didn't desire to preserve fertility were selected for hysterectomy after shorter courses of chemotherapy, 22 of them had a complete remission (95.6%), the total average courses of chemotherapy was 4.2. Of twenty-seven chemorefractory cases who were suspected of a refractory isolated lesion in the uterus, delayed hysterectomy as an adjunct to chemotherapy was performed, 20 of them got a complete remission (71.1%), the total average courses of chemotherapy were 9.4. Emergency hysterectomy is indicated in 18 patients with uterine perforation or life-threatening hemorrhage, 17 cases had a complete remission (94.4%), the total average courses of chemotherapy were 7.6.

CONCLUSION:

Although the development of effective chemotherapy has resulted in improved survival of patients with gestational trophoblastic tumor, hysterectomy remains an important adjuncts in the treatment of a selected subset of patients; in order to operate more completely and prevent recurrence, it's better to perform extended hysterectomy for the indicated patients.

• Authors: Y Xiang, X Yang, J Du, H Song
• Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih (Chin Med Sci J) Vol. 15 Issue 1 Pg. 45-8 (Mar 2000) ISSN: 1001-9294 [Print] China
• PMID: 12899400 (Publication Type: Journal Article)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Choriocarcinoma (drug therapy, surgery)
• Combined Modality Therapy
• Female
• Gestational Trophoblastic Disease (drug therapy, surgery)
• Humans
• Hydatidiform Mole, Invasive (drug therapy, surgery)
• Hysterectomy (methods)
• Middle Aged
• Neoplasm Recurrence, Local (prevention & control)
• Pregnancy
• Prognosis
• Retrospective Studies
• Uterine Neoplasms (drug therapy, surgery)