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Phase II trials of interferons-alpha and -beta in advanced sarcomas.

Abstract
Interferons (IFNs)-alpha and -beta were administered to patients with metastatic sarcomas in two different Eastern Cooperative Oncology Group studies. In one study, patients received IFN-alpha 2b, 20 million units/m2 i.v. 5 days/week x 4, then 10 million units s.c.t.i.w. In the second study, patients received IFN-beta ser 180 million units t.i.w. Of 87 patients evaluable for response, there were three responses in 64 patients (5%) treated with IFN-alpha-2b and no responses in 23 patients treated with IFN-beta ser. Severe or life-threatening fatigue with decline in performance status complicated treatment of 37% of patients receiving IFN-alpha 2b and 17% of patients receiving IFN-beta ser. Further investigation of IFNs in sarcomas should depend on evidence from preclinical studies demonstrating synergistic effects of IFNs combined with a cytoreductive modality which has proven activity in these malignancies.
AuthorsE C Borden, K Kim, L Ryan, R H Blum, M Shiraki, D C Tormey, R L Comis, R G Hahn, D R Parkinson
JournalJournal of interferon research (J Interferon Res) Vol. 12 Issue 6 Pg. 455-8 (Dec 1992) ISSN: 0197-8357 [Print] UNITED STATES
PMID1289413 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Interferon-alpha
  • Recombinant Proteins
  • Interferon beta-1b
  • Interferon-beta
  • interferon alfa-2b
  • Interferon beta-1a
Topics
  • Adult
  • Aged
  • Drug Administration Schedule
  • Female
  • Humans
  • Infusions, Intravenous
  • Injections, Subcutaneous
  • Interferon beta-1a
  • Interferon beta-1b
  • Interferon-alpha (therapeutic use)
  • Interferon-beta (therapeutic use)
  • Male
  • Middle Aged
  • Recombinant Proteins
  • Sarcoma (secondary, therapy)
  • Soft Tissue Neoplasms (therapy)
  • Treatment Outcome

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