Granuloma annulare masquerading as molluscum contagiosum-like eruption in an HIV-positive African woman.

Abstract

A 33-year-old African woman who was HIV positive and being treated with zidovudine and zalcitabine presented with a 4-week history of a generalized pruritic rash superficially resembling molluscum contagiosum. The appearance of the lesions appeared to coincide with a dramatic decrease in her peripheral CD8+, and to a lesser extent, CD4+ T-lymphocyte count. Hematologic investigations revealed anemia with eosinophilia and she had a strongly positive Strongyloides antibody test. The eruption persisted despite appropriate antihelminthic treatment and temporary withdrawal of antiretroviral therapy. Histologic examination showed ill-defined nodules of necrobiotic collagen with surrounding palisading mononuclear cell infiltrate consistent with granuloma annulare. The rash disappeared spontaneously over several weeks.

• Authors: Moses S Kapembwa, Saleem K Goolamali, Ashley Price, Susan Boyle
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 49 Issue 2 Suppl Case Reports Pg. S184-6 (Aug 2003) ISSN: 0190-9622 [Print] United States
• PMID: 12894118 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-HIV Agents
• Mebendazole

Topics

• AIDS-Related Opportunistic Infections (diagnosis, drug therapy, pathology)
• Adult
• Anti-HIV Agents (administration & dosage)
• Biopsy, Needle
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Granuloma Annulare (diagnosis, drug therapy, pathology)
• HIV Seropositivity
• Humans
• Immunohistochemistry
• Lower Extremity
• Mebendazole (administration & dosage)
• Molluscum Contagiosum (diagnosis, drug therapy, pathology)
• Risk Assessment
• Treatment Outcome
• Upper Extremity