Presence of Vicia graminea or Vicia unijuga lectin-binding (Vgu) glycoproteins with and without Thomsen-Friedenreich (T) antigen in normal human seminal plasma.

Abstract

Vgu glycoprotein (Vicia graminea lectin- or Vicia unijuga lectin-binding glycoprotein) has been reported as oncofetal antigen, which is found in many kind of tumor tissues, amniotic fluid and fetal membranes. In autoradiography with an 125I-labeled Vicia unijuga lectin (VUA) probe and an 125I-labeled Arachis hypogaea lectin (PNA, anti-T lectin) probe, seminal plasma samples of eight healthy men gave 2-7 Vgu glycoproteins without T antigen, 1-2 Vgu glycoproteins with Thomsen-Friedenreich antigen (T antigen) and 1-8 T-antigen glycoproteins, respectively. These results show that in addition to T-antigen glycoproteins, normal human seminal plasma contains Vgu glycoproteins and Vgu glycoproteins with T antigen as seminal plasma components as well as other tumor markers such as CA19-9, CA-125 and CEA.

• Authors: Y Yamaguchi, K Otsuka, Y Habu, K Ohyama, T Kurotsu, T Ookawara, S Ohkuma, T Yamakawa, K Suzuki
• Journal: Research communications in molecular pathology and pharmacology (Res Commun Mol Pathol Pharmacol) Vol. 110 Issue 5-6 Pg. 293-302 ( 2001) ISSN: 1078-0297 [Print] United States
• PMID: 12889521 (Publication Type: Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Glycoproteins
• Heat-Shock Proteins
• Thomsen-Friedenreich antigen
• Ribonucleases
• RIDA protein, human

Topics

• Antigens, Tumor-Associated, Carbohydrate (isolation & purification)
• Autoradiography
• Biomarkers, Tumor (isolation & purification)
• Glycoproteins (isolation & purification)
• Heat-Shock Proteins
• Humans
• Male
• Ribonucleases
• Semen (metabolism)