Methotrexate in recurrent postpericardiotomy syndrome.

Abstract

The postpericardiotomy syndrome occurs in up to one-third of children undergoing cardiac surgery. Its treatment includes anti-inflammatory agents, diuresis, and drainage of effusions. Administration of steroids can have a dramatic effect, but is limited by adverse effects. Usually the syndrome lasts weeks only, and persistence beyond six months is exceptional. We describe a rare case of chronic postpericardiotomy syndrome, with recurrent pericardial effusions and steroid dependency, that was treated successfully with a low weekly dose of methotrexate.

• Authors: Nili Zucker, Aviva Levitas, Eli Zalzstein
• Journal: Cardiology in the young (Cardiol Young) Vol. 13 Issue 2 Pg. 206-8 (Apr 2003) ISSN: 1047-9511 [Print] England
• PMID: 12887082 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Methotrexate

Topics

• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Child
• Humans
• Male
• Methotrexate (therapeutic use)
• Postpericardiotomy Syndrome (drug therapy)