[Impact of anthelminthic therapy for opisthorchiasis on the biochemical parameters of hepatic function].

Abstract

A response of a complex of biochemical parameters of hepatic function to therapeutic exposures was studied at different stages of development of Opisthorchis invasion. The activity of AST, ALT, GGT, GGT, AP, AM, and CE and the concentration of bilirubin, cholesterol, and glucose in the sera from 232 patients with acute or chronic opisthorchiasis were studied. Their study was conducted in several steps: before treatment, after a course of pathogenetic therapy, 1-3 days after antihelminthic therapy with bilthricide and azinox, in early (following 1-3 months) and late (following more than 6 months) residual periods. Pathogenetic therapy was found to alleviate an acute inflammatory process in the liver, but without eliminating cholestasis completely. Antihelminthic therapy improved the results of hepatic tests in different periods after treatment for acute or chronic opisthorchiasis in relation to the rate of compensation of structural lesions. By and large, after pathogenetic and antihelminthic therapy for opisthorchiasis the parameters characterizing the cytolytic syndrome became more rapidly than those that reflect the biliary system. However, there was no complete recovery of impaired hepatic and pancreatic functions throughout the follow-up.

• Authors: I V Bakshtanovskaia, T F Stepanova, A L Shonin, O V Ponomareva, V K Terekhina, N V Kholodkovskaia
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 2003 Apr-Jun Issue 2 Pg. 10-5 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Effekt terapii na biokhimicheskie pokazateli funktsii pecheni pri opistorkhoze.
• PMID: 12886584 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anthelmintics
• Biomarkers
• Blood Glucose
• azinox
• Praziquantel
• Cholesterol
• gamma-Glutamyltransferase
• Aspartate Aminotransferases
• Alanine Transaminase
• Cholinesterases
• Alkaline Phosphatase
• alpha-Amylases
• Bilirubin

Topics

• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Anthelmintics (administration & dosage, therapeutic use)
• Aspartate Aminotransferases (blood)
• Bilirubin (blood)
• Biomarkers (blood)
• Blood Glucose (analysis)
• Cholesterol (blood)
• Cholinesterases (blood)
• Humans
• Liver Function Tests
• Opisthorchiasis (blood, drug therapy, metabolism)
• Praziquantel (administration & dosage, analogs & derivatives, therapeutic use)
• alpha-Amylases (blood)
• gamma-Glutamyltransferase (blood)