Abstract | PURPOSE: To evaluate the feasibility and efficacy of a concomitant partial bladder boost schedule in radiotherapy for invasive bladder cancer, coupling a limited boost volume with shortening of the overall treatment time. METHODS AND MATERIALS: Between 1994 and 1999, 50 patients with a T2-T4 N0M0 transitional cell carcinoma of the bladder received radiotherapy delivered in a short overall treatment time with a concomitant boost technique. With this technique a dose of 40 Gy in 2-Gy fractions was administered to the small pelvis with a concomitant boost limited to the bladder tumor area plus margin of 15 Gy in fractions of 0.75 Gy. The total tumor dose was 55 Gy in 20 fractions in 4 weeks. Toxicity was scored according to EORTC/RTOG toxicity criteria. RESULTS: The feasibility of the treatment was good. Severe acute toxicity >/=G3 was observed in seven patients (14%). Severe late toxicity >/=G3 was observed in six patients (13%). Thirty-seven patients (74%) showed a complete and five (10 %) a partial remission after treatment. The actuarial 3-year freedom of local progression was 55%. CONCLUSION: In external radiotherapy for muscle invasive bladder cancer a concomitant boost technique coupling a partial bladder boost with shortening of the overall treatment time provides a high probability of local control with acceptable toxicity.
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Authors | Floris J Pos, Geertjan van Tienhoven, Maarten C C M Hulshof, Kees Koedooder, Dionisio González González |
Journal | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
(Radiother Oncol)
Vol. 68
Issue 1
Pg. 75-80
(Jul 2003)
ISSN: 0167-8140 [Print] Ireland |
PMID | 12885455
(Publication Type: Journal Article)
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Topics |
- Aged
- Aged, 80 and over
- Carcinoma
(mortality, pathology, radiotherapy)
- Dose Fractionation, Radiation
- Female
- Humans
- Intestine, Large
(radiation effects)
- Intestine, Small
(radiation effects)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Survival Rate
- Time Factors
- Urinary Bladder
(radiation effects)
- Urinary Bladder Neoplasms
(mortality, pathology, radiotherapy)
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