Abstract |
Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP- B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitation with purified CENP-B. The activities correlated with ACA titres and were closely associated with Raynaud's phenomenon. Patients with CREST symptoms ( calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) showed higher activities than those with no symptoms. Our results suggest that autoimmune responses to native CENP-B may have an important role in the pathogenesis of scleroderma.
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Authors | Y Muro, Y Matsumoto, M Ohashi |
Journal | Archives of dermatological research
(Arch Dermatol Res)
Vol. 284
Issue 7
Pg. 396-9
( 1992)
ISSN: 0340-3696 [Print] Germany |
PMID | 1288420
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Autoantigens
- CENPB protein, human
- Centromere Protein B
- Chromosomal Proteins, Non-Histone
- DNA-Binding Proteins
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Topics |
- Autoantibodies
(blood)
- Autoantigens
(immunology)
- Centromere Protein B
- Chromosomal Proteins, Non-Histone
(immunology, metabolism)
- DNA-Binding Proteins
(immunology, metabolism)
- Humans
- Precipitin Tests
- Raynaud Disease
(immunology)
- Sensitivity and Specificity
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