Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer.

Abstract

Two mutations of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) may lead to a decreased activity of the enzyme. These mutations may change a risk of some cancers. We evaluated these two polymorphisms of MTHFR in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NCSCL). All lung cancer patients had statistically significantly higher percentage of MTHFR 677TT genotype in comparison with non-cancer controls. There were no statistically significant differences in the distribution of MTHFR 1298 genotypes. Neither of the polymorphisms presented any statistically significant differences between SCLC and NSCLC.

• Authors: Krzysztof Siemianowicz, Jan Gminski, Wojciech Garczorz, Natalia Slabiak, Malgorzata Goss, Marek Machalski, Helena Magiera-Molendowska
• Journal: Oncology reports (Oncol Rep) 2003 Sep-Oct Vol. 10 Issue 5 Pg. 1341-4 ISSN: 1021-335X [Print] Greece
• PMID: 12883704 (Publication Type: Journal Article)

Chemical References

• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Carcinoma, Non-Small-Cell Lung (genetics)
• Carcinoma, Small Cell (genetics)
• Female
• Genotype
• Humans
• Lung Neoplasms (genetics)
• Male
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Polymorphism, Genetic