Myocardial oxygen supply under critical conditions, the effects of hemodilution and fluorocarbons.

Abstract

This article reviews the factors influencing myocardial oxygen supply and demand. The regulative mechanisms in coronary blood flow, especially in critical conditions, are explained. Myocardial oxygenation in coronary artery disease is discussed with special reference to pharmacological intervention. An extensive evaluation of the effects of hemodilution on both the healthy and diseased heart is presented. Effects of hemodilution with fluorocarbons for the treatment or prevention of myocardial ischemia are shown with the aid of intramyocardial oxygen partial pressure measurements.

• Authors: M Fennema, W Erdmann, N S Faithfull
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 317 Pg. 527-44 ( 1992) ISSN: 0065-2598 [Print] United States
• PMID: 1288170 (Publication Type: Journal Article, Review)

Chemical References

• Blood Substitutes
• Fluorocarbons

Topics

• Animals
• Blood Substitutes (therapeutic use)
• Coronary Circulation
• Coronary Disease (physiopathology, therapy)
• Fluorocarbons (therapeutic use)
• Hemodilution
• Homeostasis
• Humans
• Models, Cardiovascular
• Myocardial Infarction (physiopathology, therapy)
• Myocardium (metabolism)
• Oxygen Consumption