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Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT.

Abstract
Presymptomatic diagnosis of the loss of nigrostriatal neurons that characterises Parkinson's disease, is a crucial issue for future neuroprotective therapies as degeneration exceeds 70 to 80% when symptoms appear. Here we propose an early diagnosis method that utilises single photon emission computerized tomography (SPECT) coupled to the iodine-123-labelled selective dopamine transporter ligand N-(3-ioprop-2E-enyl)-2-beta-(4-methylphenyl)nortropane ((123)I-PE2I), applying Logan's graphical method for quantification. Sequential (123)I-PE2I SPECT acquisitions were performed in nonhuman primates chronically treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine according to a regimen that consistently produces a progressive Parkinsonian state. While classical neurological examination only allows detection of Parkinsonian signs at Day 12 of the protocol of intoxication, the mean distribution volume ratio calculated according to Logan's graphical method is significantly decreased from Day 6 onward, i.e., when animals are clinically normal. (123)I-PE2I SPECT is a very sensitive method to detect presymptomatic lesions of nigrostriatal neurons and the first to be experimentally validated. It could now be used clinically for early diagnosis and follow-up of neuroprotective treatment.
AuthorsCaroline Prunier, Erwan Bézard, Jérôme Montharu, Marina Mantzarides, Jean-Claude Besnard, Jean-Louis Baulieu, Christian Gross, Denis Guilloteau, Sylvie Chalon
JournalNeuroImage (Neuroimage) Vol. 19 Issue 3 Pg. 810-6 (Jul 2003) ISSN: 1053-8119 [Print] United States
PMID12880809 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dopamine Agents
  • I123-PE2I
  • Iodine Radioisotopes
  • Nortropanes
  • Radiopharmaceuticals
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Topics
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Behavior, Animal (drug effects)
  • Dopamine Agents
  • Female
  • Image Processing, Computer-Assisted
  • Iodine Radioisotopes (pharmacokinetics)
  • Macaca fascicularis
  • Nortropanes (pharmacokinetics)
  • Parkinson Disease, Secondary (chemically induced, diagnosis, diagnostic imaging)
  • Radiopharmaceuticals (pharmacokinetics)
  • Tomography, Emission-Computed, Single-Photon

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