Abstract |
We describe the case of a 64-year-old woman with isolated severe factor X deficiency associated with kappa light chain myeloma. At the time of diagnosis there was no evidence for amyloidosis. Complete remission (CR) of myeloma as well as normalization of factor X levels were achieved after cytostatic chemotherapy. Subsequently, factor X deficiency recurred twice without any evidence for relapse of myeloma. The first time factor X normalized again following cytostatic treatment, the second time, however, factor X deficiency was refractory to chemotherapy. Finally, relapse of myeloma became evident associated with rapidly progressing, systemic amyloidosis, which was fatal within a few months. Initially, factor X infusion studies showed a normal recovery, but when amyloidosis became overt the recovery decreased to 0%. We assume that factor X deficiency was due to a binding of factor X to kappa light chains associated with the proliferation of the malignant myeloma cell clone.
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Authors | I Schwarzinger, M Stain-Kos, P Bettelheim, I Pabinger, P Kyrle, P Kalhs, S Kapiotis, U Jäger, K Lechner |
Journal | Thrombosis and haemostasis
(Thromb Haemost)
Vol. 68
Issue 6
Pg. 648-51
(Dec 07 1992)
ISSN: 0340-6245 [Print] Germany |
PMID | 1287879
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Factor X
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Topics |
- Amyloidosis
(etiology)
- Antineoplastic Agents
(therapeutic use)
- Blood Coagulation Tests
- Factor X
(administration & dosage, metabolism, pharmacokinetics)
- Factor X Deficiency
(complications, drug therapy)
- Female
- Half-Life
- Humans
- Infusions, Intravenous
- Middle Aged
- Multiple Myeloma
(blood, complications, drug therapy)
- Neoplasm Recurrence, Local
(complications)
- Recurrence
- Remission Induction
(methods)
- Time Factors
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