The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-taxane derived mimics of taxol?

Abstract

In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon cancer cell line SW480 that their constituent parts do not.

• Authors: Joshua Howarth, Padraic Kenny, Susan McDonnell, Aine O'Connor
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 13 Issue 16 Pg. 2693-7 (Aug 18 2003) ISSN: 0960-894X [Print] England
• PMID: 12873496 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Bridged-Ring Compounds
• Taxoids
• Guanosine
• taxane
• Paclitaxel

Topics

• Antineoplastic Agents, Phytogenic (chemical synthesis, pharmacology)
• Bridged-Ring Compounds
• Cell Line, Tumor (drug effects)
• Colonic Neoplasms
• Drug Design
• Drug Screening Assays, Antitumor
• Guanosine (analogs & derivatives)
• Humans
• Microtubules (drug effects)
• Paclitaxel (analogs & derivatives)
• Structure-Activity Relationship
• Taxoids