Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation.

Abstract

We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37%) of 94 cases and 45 (51%) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (0/6), 0% (0/25), and 56% (35/63), respectively (P < .001), and for Cav-2, 0% (0/6), 13% (3/23), and 70% (42/60), respectively (P < .001). Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43% (20/46) of grade 3 tumors without squamous differentiation (P < .001). These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation.

• Authors: Andrew Fong, Ediberto Garcia, Lucas Gwynn, Michael P Lisanti, Melissa J Fazzari, Maomi Li
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 120 Issue 1 Pg. 93-100 (Jul 2003) ISSN: 0002-9173 [Print] England
• PMID: 12866378 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers, Tumor
• CAV1 protein, human
• Caveolin 1
• Caveolin 2
• Caveolins

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma in Situ (metabolism, pathology)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Carcinoma, Transitional Cell (metabolism, pathology)
• Caveolin 1
• Caveolin 2
• Caveolins (metabolism)
• Cell Transformation, Neoplastic
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neoplasm Invasiveness
• Urinary Bladder Neoplasms (metabolism, pathology)
• Urothelium (metabolism, pathology)