Abstract | BACKGROUND: METHODS: Forty anesthetized, spontaneously breathing dogs (18 +/- 1 kg) underwent laparotomy. A suture line was placed around the spleen to produce a splenic rupture with hilar vascular injury by pulling the exteriorized lines after incision closure. Intra-abdominal blood loss was measured directly, immediately after the animal was killed. Dogs were randomly assigned to four groups (n = 10 per group): Untreated controls were killed 20 (CT20) or 40 (CT40) minutes after splenic rupture to measure blood loss directly. Treatment groups received (20 minutes after spleen rupture) lactated Ringer's (LR), 33 mL/kg over 15 minutes, or 7.5% NaCl/6% dextran 70 (HSD), 4 mL/kg over 4 minutes. Blood loss was measured 40 minutes after spleen rupture. RESULTS: Mean arterial pressure dropped from an average value of 103 +/- 3 mm Hg to 67 +/- 5 mm Hg during the first 20 minutes and was partially restored afterward in all groups, with no significant differences between them. No resuscitation was associated with low cardiac output, whereas HSD restored and LR overshot baseline cardiac output. Intra-abdominal blood loss was 30 +/- 4, 38 +/- 4, 43 +/- 5, and 42 +/- 5 mL/kg for groups CT20, CT40, HSD, and LR, respectively, with no statistical significance between groups. CONCLUSION:
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Authors | Edson Y Varicoda, Luiz F Poli de Figueiredo, Ruy J Cruz Jr, Leonardo E Silva, Mauricio Rocha e Silva |
Journal | The Journal of trauma
(J Trauma)
Vol. 55
Issue 1
Pg. 112-7
(Jul 2003)
ISSN: 0022-5282 [Print] United States |
PMID | 12855889
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isotonic Solutions
- Ringer's Lactate
- Saline Solution, Hypertonic
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Topics |
- Animals
- Dogs
- Fluid Therapy
(methods)
- Hemodynamics
- Hemorrhage
(etiology, therapy)
- Isotonic Solutions
(therapeutic use)
- Male
- Ringer's Lactate
- Saline Solution, Hypertonic
(therapeutic use)
- Splenic Rupture
(complications)
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