[A case of advanced gastric cancer with lymphangitis carcinomatosa of the lung, successfully treated with paclitaxel and TS-1].

Abstract

A 65-year-old man, who had been admitted to another hospital with complaints of severe cough and dyspnea, was transferred to our hospital for the further examination and therapy. The patient was diagnosed with advanced gastric cancer (type-3) with lymphangitis carcinomatosa of the lung. He was treated with combination therapy of 5-FU and cisplatin, and showed a complete response. However, because resistance was seen in the lymphangitis of the lung and the gastric lesion; and a liver metastasis was also seen, we attempted combination therapy with paclitaxel and TS-1. Sixty mg/m2/day of paclitaxel was administered intravenously on day 1 and 8, and TS-1 of 60-80 mg/m2/day was administered orally for 2 weeks followed by one drug-free week. After 2 courses of the combination therapy, the patient achieved a remarkable response in the lymphangitis carcinomatosa of the lung, but a slight response in the liver metastasis and gastric lesion.

• Authors: Takuya Watanabe, Hidehiro Kawabata, Ikuo Takase, Akitoshi Murata, Haruhiko Nakajima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 30 Issue 6 Pg. 849-53 (Jun 2003) ISSN: 0385-0684 [Print] Japan
• PMID: 12852355 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Pyridines
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Paclitaxel
• Cisplatin
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cisplatin (administration & dosage)
• Drug Combinations
• Drug Resistance, Neoplasm
• Fluorouracil (administration & dosage)
• Humans
• Liver Neoplasms (secondary)
• Lung Neoplasms (complications)
• Lymphangitis (drug therapy)
• Male
• Oxonic Acid (administration & dosage)
• Paclitaxel (administration & dosage)
• Pyridines (administration & dosage)
• Stomach Neoplasms (drug therapy, pathology)
• Tegafur (administration & dosage)