[Anaphylactic shock due to modified fluid gels: 2 case reports].

Abstract

UNLABELLED:

Colloid solutions can give severe anaphylactic accidents. We are reporting two cases from our department.

FIRST CASE:

a sixty eight years old man perfused with Plasmion solution (Gelatin plasma substitute) before spinal anesthesia, presented sudden hypotension and diffuse skin rush. Second case: a twelve years old girl, receiving a Plasmion solution to correct a hypovolemic shock in I.C.U, presented a severe bronchospasm and a worsening of the hypotension. These accidents are explained by immunologic reactions or by direct histamine release. Their incidence is between 0.01 and 0.8 percent depending on the used solution. They are prevented by an antihistaminic premedication for the gelatin plasma substitutes and by an haptenic inhibition for Dextran (polysaccharide plasma substitutes). The new colloid solutions, based on hydroxyethylstarch, seems to give much less allergic reactions.

• Authors: G Hayeck, A Yazigi, P Yazbeck, M C Antakly
• Journal: Le Journal medical libanais. The Lebanese medical journal (J Med Liban) Vol. 40 Issue 2 Pg. 84-6 ( 1992) ISSN: 0023-9852 [Print] Lebanon
• Vernacular Title: Choc anaphylactique aux gélatines fluides modifiées: à propos de deux cas.
• PMID: 1285066 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dextrans
• Histamine Antagonists
• Plasma Substitutes
• plasmion
• Gelatin

Topics

• Aged
• Anaphylaxis (chemically induced, epidemiology, immunology, prevention & control)
• Child
• Dextrans (therapeutic use)
• Female
• Gelatin (adverse effects)
• Histamine Antagonists (therapeutic use)
• Humans
• Male
• Plasma Substitutes (adverse effects)
• Premedication