[Multicenter study of the effectiveness and tolerability of desloratadine in seasonal allergic rhinitis].

Abstract

INTRODUCTION:

The authors appraised the clinical efficacy of desloratadine in patients with seasonal allergic rhinitis and rhinoconjunctivitis.

PATIENTS AND METHODS:

An open, two-week trial was conducted on 428 patients between 3 June and 31 July 2002 in 11 centres. Nasal obstruction, rhinorrhea, sneezing, and itching as well as ocular clinical signs were characterized using a symptom score. Desloratadine tablet was administered in 5 mg doses. After two weeks of treatment, the symptom score was re-evaluated. Potential adverse events that had occurred during the treatment period were recorded.

RESULTS:

Desloratadine significantly alleviated all four nasal symptoms and ocular effectively. In particular, treatment resulted from 76 percent to 12% percent decrease of overall symptom score. One of the participants discontinued treatment due to the occurrence of adverse effects.

CONCLUSION:

These results demonstrate that desloratidine is a safe and effective systemic antihistamine--with complex antiallergic effect--for the therapy of seasonal allergic rhinitis and rhinoconjunctivitis. It can reduce nasal congestion with greater magnitude than other known antihistamines.

• Authors: Henriette Farkas
• Journal: Orvosi hetilap (Orv Hetil) Vol. 144 Issue 21 Pg. 1021-4 (May 25 2003) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Desloratadin hatékonyságának és tolerálhatóságának multicentrikus vizsgálata szezonális allergiás rhinitisben.
• PMID: 12847854 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Histamine H1 Antagonists, Non-Sedating
• Loratadine
• desloratadine

Topics

• Adult
• Female
• Histamine H1 Antagonists, Non-Sedating (adverse effects, therapeutic use)
• Humans
• Loratadine (adverse effects, analogs & derivatives, therapeutic use)
• Male
• Middle Aged
• Rhinitis, Allergic, Seasonal (drug therapy)
• Treatment Outcome