| Abstract | INTRODUCTION: Coeliac disease (gluten sensitive enteropathy) is a very frequent disease appearing in variegated clinical form. In the last decade--concerning the immunogenetic and immunopathological aspects of the disease many of new recognition came to alight. AIM: As the disease can lay hidden in its non classical manifesting form for a very long time, authors wished to study the efficacy of screening, which may be introduced for patients attending immunological outpatient care service. PATIENTS, METHODS AND RESULTS: In the frame of nation-wide patient care, out of the 200 potential patients sent for immunological check up, various form of coeliac disease was diagnosed in 20 cases. Among these cases there are two--presented for the first time--which are connected to bone marrow transplantation. Based on the immunogenetics and autoantibody serology as well as on small intestine biopsies the following conclusions were made. CONCLUSION: 1. Coeliac disease in Hungary is very frequent. Hidden disease should be considered first of all in cases of malabsorption symptoms. 2. Demonstration of autoantibodies on wide-scale palette helps to state the diagnosis based on the systematic auto-immune disease connection. 3. Study of Human Leukocyte Antigen allotype (HLA-DQA1*0501/DQBI*02) applied as marker can considerably support the suspicion of disease. 4. Histology test of the small intestine cannot be omitted. |
| Authors | Katalin Kilián, Kata Miklós, Katalin Rajczy, Andrea Sipos, Lilla Lengyel, László Nemes, Gyözö Petrányi, Katalin Pálóczi
(Affiliation: Országos Gyógyintézeti Központ, Immunológiai és Allergológiai Osztály, Budapest.)
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| Journal | Orvosi hetilap
(Orv Hetil)
Vol. 144
Issue 22
Pg. 1069-76
(Jun 1 2003)
ISSN: 0030-6002 Hungary |
| Vernacular Title | A felnóttkori coeliakia felismerésének lehetósége szúróvizsgálatok alkalmazásával immunológiai szakambulancián jelentkezó betegekben. |
| PMID | 12847816
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Autoantibodies
- HLA-DQ Antigens
- Immunoglobulins
|
| Topics |
- Adolescent
- Adult
- Age of Onset
- Aged
- Ambulatory Care
- Autoantibodies
(blood)
- Biopsy
- Celiac Disease
(diagnosis, genetics, immunology)
- Female
- HLA-DQ Antigens
(genetics)
- Humans
- Immunoglobulins
(blood)
- Intestine, Small
(pathology)
- Male
- Mass Screening
(methods)
- Middle Aged
|
