Comparison of Tc-99m-GSA scintigraphy with hepatic fibrosis and regeneration in patients with hepatectomy.

Abstract

OBJECTIVE:

Liver regeneration after hepatectomy is correlated with liver fibrosis. Retrospectively, we compared three quantitative indices (HH15, LHL15 and LU15) of Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (Tc-99m-GSA) liver scintigraphy with liver fibrosis; in particular, we compared the HH15 index and the rate of remnant liver regeneration.

METHODS:

Fifty-three patients who had undergone hepatectomy were enrolled in this study. The non-neoplastic parts of their resected specimens were divided into 5 groups (F0-F4) according to the degree of liver fibrosis, as determined using the New Inuyama classification system: F0, no fibrosis (n = 12); F1, portal fibrosis widening (n = 12); F2, portal fibrosis widening with bridging fibrosis (n = 14); F3, bridging fibrosis plus lobular distortion (n = 7); F4, liver cirrhosis (n = 8).

RESULTS:

When the cases were divided into a no or mild fibrosis group (F0 and F1) and a moderate or severe fibrosis or cirrhosis group (F2, F3 and F4), all of the indices were significantly different between the two groups. In this analysis, the areas (Az) under the receiver operating characteristic (ROC) curves for the HH15 and LHL15 indices were very similar, while the Az for the LU15 index was smaller. An HH15 index equal to 0.52 was the most accurate, producing a 79.3% sensitivity and a 75.0% specificity rating. When 18 patients that had received a CT scan one month after hepatectomy were divided into 2 groups according to their HH15 value (group A, HH15 < or = 0.52; group B, HH15 > 0.52), group A exhibited a better regeneration rate.

CONCLUSION:

Tc-99m-GSA scintigraphy is well correlated with liver fibrosis and may be useful for non-invasive, preoperative evaluations of liver fibrosis. The HH15 index, in particular, may be useful for predicting the rate of liver regeneration after hepatectomy.

• Authors: Toshihiro Iguchi, Shuhei Sato, Yoshihiro Kouno, Yoshihiro Okumura, Shiro Akaki, Toshihide Tsuda, Keita Kobayashi, Susumu Kanazawa, Yoshio Hiraki
• Journal: Annals of nuclear medicine (Ann Nucl Med) Vol. 17 Issue 3 Pg. 227-33 (May 2003) ISSN: 0914-7187 [Print] Japan
• PMID: 12846545 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Validation Study)

Chemical References

• Radiopharmaceuticals
• Technetium Tc 99m Aggregated Albumin
• technetium Tc 99m DTPA-galactosyl-human serum albumin
• Technetium Tc 99m Pentetate

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Hepatocellular (diagnostic imaging, surgery)
• False Positive Reactions
• Female
• Hepatectomy (adverse effects)
• Humans
• Liver (diagnostic imaging, surgery)
• Liver Cirrhosis (classification, diagnostic imaging, etiology, pathology)
• Liver Function Tests (methods)
• Liver Neoplasms (diagnostic imaging, secondary, surgery)
• Liver Regeneration
• Male
• Middle Aged
• Postoperative Care
• Preoperative Care
• Prognosis
• Radionuclide Imaging
• Radiopharmaceuticals
• Reproducibility of Results
• Sensitivity and Specificity
• Technetium Tc 99m Aggregated Albumin
• Technetium Tc 99m Pentetate
• Treatment Outcome