Abstract | OBJECTIVE: DESIGN AND SETTING: Randomized interventional prospective study in the medical and surgical ICU of a tertiary university hospital. PATIENTS: MEASUREMENTS AND RESULTS: Patients with moderate hypophosphatemia (<0.65 and >0.40 mmol/l; n=37) were randomized into two groups: group 1 received 30 mmol potassium phosphate intravenously in 50 ml saline over 2 h, and group 2 received 30 mmol potassium phosphate in 100 ml saline over 4 h. Patients with severe hypophosphatemia (<0.40 mmol/l; n=10) were also randomized into two groups: group 3 received 45 mmol potassium phosphate intravenously in 100 ml saline over 3 h, and group 4 received 45 mmol potassium phosphate in 100 ml saline over 6 h. Electrolytes, blood gas, renal function were monitored until day 3; urine was collected during and until 6 h after infusions. The overall efficacy of the protocols was 98% by the end of the infusion. There was no statistical difference in phosphate values between groups at the end of infusion or at 24 h. No adverse events were noted; one patient had an increase in serum potassium to 6.1 mmol/l. Phosphaturia in all groups was elevated as evidenced by fractional excretion above 20%. CONCLUSIONS:
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Authors | Thierry Charron, Francis Bernard, Yoanna Skrobik, Nathalie Simoneau, Nadine Gagnon, Martine Leblanc |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 29
Issue 8
Pg. 1273-8
(Aug 2003)
ISSN: 0342-4642 [Print] United States |
PMID | 12845429
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Phosphates
- Potassium Compounds
- potassium phosphate
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Topics |
- Aged
- Female
- Humans
- Hypophosphatemia
(drug therapy, physiopathology)
- Infusion Pumps
- Intensive Care Units
- Male
- Middle Aged
- Phosphates
(administration & dosage, therapeutic use)
- Potassium Compounds
(administration & dosage, therapeutic use)
- Prospective Studies
- Treatment Outcome
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