Abstract | INTRODUCTION: CASE REPORTS: Case 1. A 56 year-old woman, suffering from a colorectal cancer, developed a sudden acneiform eruption after 6 cures of cetuximab, at a one-week interval. She was treated with bisoprolol hemifumarate, sodium levothyroxin, cyproterone acetate and estradiol valerate. Clinical examination revealed inflammatory and follicular papulopustules localized on the face and upper chest. Comedos were absent. Itching sensations were discrete. Histopathological examination of a papulopustule revealed a folliculitis with polymorphonuclear neutrophils. PAS staining did not reveal the presence of bacteria or yeasts. Bacterial and fungal cultures were negative. Lesions faded in approximately 2 weeks following minocycline treatment (100 mg/day). Case 2. A 65 year-old man, treated by cetuximab for a colorectal adenocarcinoma, suddenly developped follicular inflammatory papulopustules on the face, trunk and extensor surfaces of both arms, after 3 weeks of treatment. Itching was discrete. Comedos were absent. Histopathology revealed the presence of a folliculitis with polymorphonuclear neutrophils. Bacteriology and mycology were negative. Lesions were partly controlled by administration of minocycline (100 mg/day) but worsened again in the days following each cure of cetuximab. DISCUSSION:
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Authors | L Walon, C Gilbeau, J-M Lachapelle |
Journal | Annales de dermatologie et de venereologie
(Ann Dermatol Venereol)
Vol. 130
Issue 4
Pg. 443-6
(Apr 2003)
ISSN: 0151-9638 [Print] France |
Vernacular Title | Eruptions acnéiformes induites par le cétuximab. |
PMID | 12843857
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents
- Cetuximab
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Topics |
- Acneiform Eruptions
(chemically induced, diagnosis, pathology)
- Adenocarcinoma
(drug therapy)
- Antibodies, Monoclonal
(adverse effects, therapeutic use)
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Biopsy
- Cetuximab
- Colorectal Neoplasms
(drug therapy)
- Diagnosis, Differential
- Drug Eruptions
(diagnosis, pathology)
- Female
- Humans
- Male
- Middle Aged
- Skin
(pathology)
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