Protected carotid stenting: clinical advantages and complications of embolic protection devices in 442 consecutive patients.

Abstract

BACKGROUND AND PURPOSE:

Periprocedural embolization of debris during carotid stenting interventions may result in neurological deficit. This study was designed to evaluate in-hospital and 30-day adverse events in patients percutaneously treated for carotid artery disease with embolic protection devices.

METHODS:

From 1999 to June 2002, a total of 442 consecutive patients underwent percutaneous angioplasty and/or stenting of the extracranial carotid artery. The endovascular procedure was conducted under embolic protection devices.

RESULTS:

The percutaneous procedure was successful in 440 of 442 patients (99.5%). No periprocedural death occurred with any embolic protection device. All in-hospital stroke/death and 30-day ipsilateral stroke/death rate was 1.1%. The overall complication rate was 3.4%. Major adverse events included 1 major stroke (0.2%), 4 intracranial hemorrhages (0.9%), 1 carotid artery wall fissuration (0.2%), and 1 diffuse cardioembolism (0.2%). Minor adverse events included 4 minor strokes (0.9%) and 4 transient ischemic attacks (0.9%). The cerebral protection device-related complications were 4 (0.9%): 1 case of abrupt closure of the internal carotid artery because of spiral dissection (0.2%), 1 case of trapped guide wire (0.2%), and 2 cases of intimal dissection (0.5%). Transient loss of consciousness, tremors, and fasciculations were present in 6 of 40 patients (15%) in whom occlusive protection devices were used.

CONCLUSIONS:

Our data suggest that percutaneous stenting of the carotid artery when a cerebral protection device is used is feasible and effective but not without potential complications. However, a long learning curve may exist for the proper use of some embolic protection devices.

• Authors: Alberto Cremonesi, Raffaella Manetti, Francesco Setacci, Carlo Setacci, Fausto Castriota
• Journal: Stroke (Stroke) Vol. 34 Issue 8 Pg. 1936-41 (Aug 2003) ISSN: 1524-4628 [Electronic] United States
• PMID: 12843347 (Publication Type: Clinical Trial, Journal Article)

Topics

• Aged
• Blood Vessel Prosthesis Implantation (adverse effects, instrumentation)
• Carotid Arteries (diagnostic imaging, surgery)
• Carotid Artery Diseases (surgery)
• Carotid Artery, Internal, Dissection (etiology)
• Embolism (etiology, prevention & control)
• Feasibility Studies
• Female
• Filtration (instrumentation, methods)
• Hospital Mortality
• Humans
• Ischemic Attack, Transient (etiology, prevention & control)
• Male
• Postoperative Complications (etiology, prevention & control)
• Prostheses and Implants (adverse effects)
• Safety
• Stents (adverse effects)
• Stroke (etiology, prevention & control)
• Treatment Outcome
• Ultrasonography