Isolation and structure of providencin: a highly oxygenated diterpene possessing a unique bicyclo[12.2.0]hexadecane ring system from the sea plume Pseudopterogorgia kallos.

Abstract	[structure: see text] Providencin (1) is a naturally occurring cytotoxin isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed bicyclo[12.2.0]hexadecane ring system and was established through spectroscopic analysis and X-ray crystallographic analysis. Providencin (1) was shown to exhibit modest anticancer activity against human breast (MCF7), lung (NCI-H460), and CNS (SF-268) cancer cell lines.
Authors	Jeffrey Marrero, Abimael D Rodríguez, Peter Baran, Raphael G Raptis
Journal	Organic letters (Org Lett) Vol. 5 Issue 14 Pg. 2551-4 (Jul 10 2003) ISSN: 1523-7060 [Print] United States
PMID	12841778 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antineoplastic Agents Diterpenes providencin
Topics	Anthozoa (chemistry) Antineoplastic Agents (chemistry, isolation & purification, pharmacology) Crystallography, X-Ray Diterpenes (chemistry, isolation & purification, pharmacology) Drug Screening Assays, Antitumor Humans Molecular Structure Tumor Cells, Cultured

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