Efficacy and tolerability of slow-release gallopamil in patients with stable exercise-inducible angina pectoris.

Abstract

The anti-ischemic properties and tolerability of a slow-release formulation (SR) of gallopamil were investigated in 118 patients with exercise-inducible ST-segment depression and stable angina pectoris in this double-blind, randomized, placebo-controlled, multicenter study. After a placebo run-in period (A) of 2-7 days and a 7-day open therapy period (B) with gallopamil SR, the patients were randomized to a double-blind 7-day period (C) to receive placebo or gallopamil SR 100 mg twice a day. Each patient was submitted to gradual upright bicycle ergometry and electrocardiography (ECG) at rest on the last 2 days of each period at 6 and 12 h postadministration (p.a.) In period C, exercise time and exercise tolerance remained significantly prolonged at 6 and 12 h after gallopamil SR administration in comparison with the placebo values. Additionally the sum of ST-segment depression and maximal ST-segment depression were significantly reduced by gallopamil SR at 6 h p.a. as were the frequency of angina attacks and nitroglycerin consumption. Four patients were withdrawn from the study because of gallopamil-related adverse events, which, however, were not serious. Constipation was noted in 2.5% of the patients. These data suggest that gallopamil SR is effective in reducing exercise-inducible ST-segment depression and increasing exercise tolerance with no serious adverse effects in patients with stable angina pectoris.

• Authors: H Kottkamp, H Gülker, K Emmerich, H P Koch, C Minge
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 20 Suppl 7 Pg. S88-94 ( 1992) ISSN: 0160-2446 [Print] United States
• PMID: 1284163 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Delayed-Action Preparations
• Gallopamil

Topics

• Adult
• Aged
• Angina Pectoris (drug therapy, physiopathology)
• Delayed-Action Preparations
• Electrocardiography
• Exercise
• Female
• Gallopamil (administration & dosage, adverse effects, therapeutic use)
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged