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A calcium conducting channel akin to a calcium pump.

Abstract
Calcium conducting channels were studied in blebs of sarcoplasmic reticulum described by Stein & Palade (1988). The calcium channels had at least three conductance states (70 pS, 50 pS and 37 pS) and were weakly selective for calcium ions, with a permeability ratio Ca2+ to K+ of about 3.4. The open probability of the channel was strongly voltage dependent, decreasing at positive membrane voltages. 10 microM ryanodine and 5 microM ruthenium red had no effect on this channel; neither did millimolar concentrations of ATP, Mg2+, caffeine, and Ca2+, implying that the calcium conducting channels are not ryanodine receptors. Several calcium pump inhibitors--namely, vanadate, AlF4-, reactive red 120, and cyclopiazonic acid--had obvious effects on the calcium conducting channels, suggesting that the calcium conducting channel of SR membrane blebs is some form of the SR calcium pump.
AuthorsJ Wang, J M Tang, R S Eisenberg
JournalThe Journal of membrane biology (J Membr Biol) Vol. 130 Issue 2 Pg. 163-81 (Nov 1992) ISSN: 0022-2631 [Print] United States
PMID1283985 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Calcium Channels
  • Indoles
  • Potassium Channels
  • Triazines
  • Ruthenium Red
  • Ryanodine
  • Vanadates
  • reactive red 120 dye
  • Calcium-Transporting ATPases
  • Magnesium
  • Calcium
  • cyclopiazonic acid
Topics
  • Animals
  • Calcium (pharmacokinetics, pharmacology)
  • Calcium Channels (drug effects, physiology)
  • Calcium-Transporting ATPases (drug effects, physiology)
  • Dose-Response Relationship, Drug
  • Indoles (pharmacology)
  • Magnesium (pharmacology)
  • Potassium Channels (drug effects, physiology)
  • Rana catesbeiana
  • Ruthenium Red (pharmacology)
  • Ryanodine (pharmacology)
  • Sarcoplasmic Reticulum (chemistry, ultrastructure)
  • Triazines (pharmacology)
  • Vanadates (pharmacology)

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