Abstract | BACKGROUND: OBJECTIVES: RESULTS: A total 32 subjects, aged from 6 to 72 years, diagnosed as having anticonvulsant hypersensitivity syndrome based on clinical and histopathological findings, were included in the study. In 22 of the 32 cases, the anticonvulsants had been administered prophylactically after craniotomy and in 10 cases for epilepsy. When the cases were assessed for skin lesions, maculopapular eruption was registered in 22, Stevens-Johnson syndrome in five, and toxic epidermal necrolysis (TEN) in five. Treatment included suspension of the offending drug and then, except for the cases with toxic epidermal necrolysis, administration of corticosteroids. The 22 cases that required anticonvulsant therapy were treated with valproic acid. In all cases, we observed rapid clinical improvement corroborated by laboratory findings. CONCLUSIONS:
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Authors | M Baba, M Karakaş, V L Aksungur, S Homan, A Yücel, M A Acar, H R Memişoglu |
Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 17
Issue 4
Pg. 399-401
(Jul 2003)
ISSN: 0926-9959 [Print] England |
PMID | 12834448
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Age Distribution
- Aged
- Anticonvulsants
(adverse effects, therapeutic use)
- Biopsy, Needle
- Child
- Cohort Studies
- Craniotomy
(methods)
- Drug Eruptions
(epidemiology, etiology, pathology)
- Drug Hypersensitivity
(diagnosis, epidemiology, etiology, pathology)
- Epilepsy
(diagnosis, drug therapy)
- Erythema Multiforme
(chemically induced, epidemiology, pathology)
- Female
- Humans
- Immunohistochemistry
- Incidence
- Intraoperative Care
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Risk Assessment
- Sex Distribution
- Stevens-Johnson Syndrome
(chemically induced, epidemiology, etiology, pathology)
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