Impairment of peripheral nervous system in patients with non-Hodgkin's lymphomas treated with CBVPM/AVBP and CHOP schedules.

Abstract

Clinical examination and conduction velocity measurements in peripheral nerves have been done on 56 patients with non-Hodgkin's lymphomas of high malignancy (NHL). It is suggested that: the evaluation of the influence of chemotherapy on peripheral nervous system (PNS) is possible by means of systematic neurological and electroneurographic studies; electroneurographic assessment is most important in the diagnosis of early subclinical stages of peripheral neuropathy; toxic influence of CBVPM/AVBP protocol on PNS is greater than CHOP schedule; impairment of PNS due to chemotherapy is reversible in patients during complete remission (CR).

• Authors: P Nowacki, D Dolińska, J Stankiewicz, H Grzelec
• Journal: Acta haematologica Polonica (Acta Haematol Pol) Vol. 23 Issue 2 Pg. 111-6 ( 1992) ISSN: 0001-5814 [Print] Poland
• PMID: 1283282 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bleomycin
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone
• Methotrexate

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bleomycin (administration & dosage, adverse effects)
• Cyclophosphamide (administration & dosage, adverse effects)
• Doxorubicin (administration & dosage, adverse effects)
• Female
• Humans
• Lymphoma, Non-Hodgkin (drug therapy, physiopathology)
• Male
• Median Nerve (drug effects, physiopathology)
• Methotrexate (administration & dosage, adverse effects)
• Middle Aged
• Neural Conduction (drug effects, physiology)
• Peroneal Nerve (drug effects, physiopathology)
• Prednisone (administration & dosage, adverse effects)
• Reflex, Abnormal (drug effects, physiology)
• Reflex, Stretch (drug effects, physiology)
• Ulnar Nerve (drug effects, physiopathology)
• Vincristine (administration & dosage, adverse effects)