Abstract | BACKGROUND: METHODS: RESULTS: ASCVD prevalence was 58%. Median Lp(a) levels for those with compared with those without ASCVD were 38 versus 35 nmol/L for whites (P = 0.49) and 100 versus 74 nmol/L for blacks, respectively (P = 0.35). Lp(a) level was associated with ASCVD among those younger than 60 years (odds ratio [OR] for +1 interquartile range of Lp(a), 1.5; P = 0.02), but not among those 60 years and older (OR, 1.0; P = 0.82; P(interaction) by age, 0.08). ORs were 1.3 for all whites (P = 0.03) and 1.1 for all blacks (P = 0.87; P(interaction)by race = 0.53). ORs of ASCVD were 1.7 for whites younger than 60 years (P = 0.01) and 1.2 for blacks younger than 60 years (P = 0.77; P(interaction) by race = 0.42). No association between apo(a) isoform size and ASCVD was present. CONCLUSION: In an incident dialysis cohort, Lp(a) level was associated with prevalent ASCVD among whites younger than 60 years, but not among blacks or those older than 60 years. Apo(a) isoform size was not associated with prevalent ASCVD. These data suggest that baseline ASCVD is unlikely to strongly confound the potential associations of Lp(a) level and prospectively ascertained ASCVD among incident dialysis patients.
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Authors | J Craig Longenecker, Josef Coresh, Santica M Marcovina, Neil R Powe, Andrew S Levey, Federico Giaculli, Nancy E Fink, Michael J Klag |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 42
Issue 1
Pg. 108-16
(Jul 2003)
ISSN: 1523-6838 [Electronic] United States |
PMID | 12830462
(Publication Type: Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins A
- Lipoprotein(a)
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Topics |
- Adult
- Age Distribution
- Aged
- Apolipoproteins A
(blood)
- Arteriosclerosis
(blood, epidemiology)
- Cohort Studies
- Comorbidity
- Cross-Sectional Studies
- Female
- Humans
- Kidney Failure, Chronic
(blood, epidemiology, therapy)
- Lipoprotein(a)
(analysis)
- Male
- Middle Aged
- Molecular Weight
- Prevalence
- Prospective Studies
- Racial Groups
- Renal Dialysis
- Risk Factors
- United States
(epidemiology)
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