Bioactive constituents from three Vismia species.

Abstract

Bioassay-guided fractionation of the methanolic extracts of Vismia baccifera, V. jefensis, and V. macrophylla against human breast, CNS, and lung cancer cell lines resulted in the isolation of a new compound, ferruginin C (1), and seven known compounds, ferruginins A (2) and B (3), vismin (4), harunganin (5), vismione B (6), deacetylvismione H (7), and deacetylvismione A (8), as active constituents. In addition, bivismiaquinone (9) and vismiaquinone (10) were obtained as inactive constituents. The structure of ferruginin C was elucidated by spectroscopic means. Compounds 6-8 were the most active, and the cytotoxic activity of compounds 2-5 and 7 is reported for the first time.

• Authors: Ahmed A Hussein, Berena Bozzi, Mireya Correa, Todd L Capson, Thomas A Kursar, Phyllis D Coley, Pablo N Solis, Mahabir P Gupta
• Journal: Journal of natural products (J Nat Prod) Vol. 66 Issue 6 Pg. 858-60 (Jun 2003) ISSN: 0163-3864 [Print] United States
• PMID: 12828475 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anthraquinones
• Antineoplastic Agents, Phytogenic
• ferruginin C

Topics

• Anthraquinones (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Breast Neoplasms
• Clusiaceae (chemistry)
• Drug Screening Assays, Antitumor
• Humans
• Lung Neoplasms
• Molecular Structure
• Neoplasms, Nerve Tissue
• Panama
• Plant Leaves (chemistry)
• Plants, Medicinal (chemistry)
• Tumor Cells, Cultured (drug effects)