Abstract |
The paper discusses preclinical tests of a new viscoelastic preparation for ophthalmosurgery. Experiments revealed that preparation Duo-Bonharen which contains hyaluronic acid prepared by bacterial fermentation is suited for clinical tests. After a 24-hour interval following administration into the anterior chamber it does not raise intraocular pressure. In experiments it has no side-effects on the eye. The dispersed form in a higher concentration (5%) adheres very well to ocular tissues and protects them adequately during surgery. The cohesive form in an optimal concentration (1.5%) can be rapidly removed from inside the eye. The properties of Duo-Bonharen in experiments are comparable with similar viscomaterials which are used. The new viscoelastic material Duo-Bonharen appears suitable for clinical tests in particular for cataract surgery.
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Authors | A al-Farzai, J Novák, F Hubálek, P Cesková, J Kvasnicka, F Langr |
Journal | Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti
(Cesk Slov Oftalmol)
Vol. 59
Issue 2
Pg. 91-7
(Mar 2003)
ISSN: 1211-9059 [Print] Czech Republic |
Vernacular Title | Duo-Bonharen--nové viskoelastikum. Experimentální studie. |
PMID | 12825399
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Duo-Bonharen
- Hyaluronic Acid
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Topics |
- Animals
- Drug Evaluation, Preclinical
- Elasticity
- Hyaluronic Acid
(administration & dosage, adverse effects, pharmacokinetics)
- Male
- Ophthalmologic Surgical Procedures
- Rabbits
- Viscosity
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