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[Duo-Bonharen--a new viscoelastic preparation. Experimental study].

Abstract
The paper discusses preclinical tests of a new viscoelastic preparation for ophthalmosurgery. Experiments revealed that preparation Duo-Bonharen which contains hyaluronic acid prepared by bacterial fermentation is suited for clinical tests. After a 24-hour interval following administration into the anterior chamber it does not raise intraocular pressure. In experiments it has no side-effects on the eye. The dispersed form in a higher concentration (5%) adheres very well to ocular tissues and protects them adequately during surgery. The cohesive form in an optimal concentration (1.5%) can be rapidly removed from inside the eye. The properties of Duo-Bonharen in experiments are comparable with similar viscomaterials which are used. The new viscoelastic material Duo-Bonharen appears suitable for clinical tests in particular for cataract surgery.
AuthorsA al-Farzai, J Novák, F Hubálek, P Cesková, J Kvasnicka, F Langr
JournalCeska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti (Cesk Slov Oftalmol) Vol. 59 Issue 2 Pg. 91-7 (Mar 2003) ISSN: 1211-9059 [Print] Czech Republic
Vernacular TitleDuo-Bonharen--nové viskoelastikum. Experimentální studie.
PMID12825399 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Duo-Bonharen
  • Hyaluronic Acid
Topics
  • Animals
  • Drug Evaluation, Preclinical
  • Elasticity
  • Hyaluronic Acid (administration & dosage, adverse effects, pharmacokinetics)
  • Male
  • Ophthalmologic Surgical Procedures
  • Rabbits
  • Viscosity

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