Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.

Abstract

In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.

• Authors: Kyung Mi Kim, Kyung Hwa Kim, Tae Cheon Kang, Won Yeon Kim, Myung ryul Lee, Hyuk Jun Jung, In Koo Hwang, Sung Bo Ko, Jae Young Koh, Moo Ho Won, Eu gene Oh, Injae Shin
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 13 Issue 14 Pg. 2273-5 (Jul 21 2003) ISSN: 0960-894X [Print] England
• PMID: 12824016 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Azoles
• Free Radical Scavengers
• Hydroxylamines
• Isoindoles
• N-t-butyl-N-hydroxylaminophenyl
• Neuroprotective Agents
• Organoselenium Compounds
• ebselen

Topics

• Animals
• Antioxidants (chemical synthesis, pharmacology)
• Azoles (pharmacology)
• Brain Ischemia (drug therapy, pathology)
• Cell Death (drug effects)
• Cell Survival (drug effects)
• Drug Design
• Electron Spin Resonance Spectroscopy
• Free Radical Scavengers (chemical synthesis, pharmacology)
• Gerbillinae
• Hippocampus (pathology)
• Hydroxylamines (chemical synthesis, pharmacology)
• Isoindoles
• Lipid Peroxidation (drug effects)
• Neurons (drug effects)
• Neuroprotective Agents (chemical synthesis, pharmacology)
• Organoselenium Compounds (pharmacology)
• Oxidation-Reduction