[Studies on 2-hydroxyestradiol 17-sulfate derived from fetoplacental unit: the antioxidant as a potential defense substance against preeclampsia].

Abstract

The antioxidant 2-hydroxyestradiol 17-sulfate (2-OH-E2-17-S) was found to be present in the placenta and to prevent the onset of preeclampsia. From experiments using rats, 2-OH-E2-17-S was confirmed to be a highly functional compound with stronger antioxidant activity than alpha-tocopherol and to sustain its antioxidant activity. 2-OH-E2-17-S was confirmed to be produced in the placenta from its precursor, estradiol 17-sulfate (E2-17-S), which is derived from fetal testosterone sulfate (TS). Since the fetal adrenal gland has been shown to convert testosterone (T) into TS, the following metabolic pathway may exist during pregnancy: T-->TS-->E2-17-S-->2-OH-E2-17-S. This fetoplacental pathway may contribute to the maintenance of healthy pregnancy. Details and the experimental outline of these discoveries are reported in this review.

• Authors: Kaori Takanashi
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 123 Issue 6 Pg. 399-411 (Jun 2003) ISSN: 0031-6903 [Print] Japan
• PMID: 12822484 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antioxidants
• Catechols
• estradiol 17-sulfate
• Estradiol
• 2-hydroxyestradiol 17-sulfate

Topics

• Animals
• Antioxidants
• Catechols (blood)
• Estradiol (analogs & derivatives, biosynthesis, blood, physiology, urine)
• Female
• Humans
• Hydroxylation
• Lipid Peroxidation
• Microsomes, Liver (metabolism)
• Placenta (metabolism)
• Pre-Eclampsia (etiology, prevention & control)
• Pregnancy
• Rats