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[Marked improvement of Lambert-Eaton myasthenic syndrome resulting from treatment for small cell lung carcinoma].

Abstract
A 68-year-old man was admitted to our hospital because of muscle weakness. A complete medical examination led to a diagnosis of small cell lung carcinoma (SCLC) with Lambert-Eaton myasthenic syndrome (LEMS) and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Four courses of chemotherapy (carboplatin + etoposide) and one of radiotherapy with a total dose of 45 Gy to the mediastinum were performed and resulted in a partial response in the SCLC. After the second course of chemotherapy, the serum level of antivoltage-gated Ca2+ channel (VGCC) antibody decreased from 190 pg/ml to 120 pg/ml. Marked improvement of the muscle weakness was recognized only after 3 courses of chemotherapy. The patient, who had had difficulty in standing, recovered enough to be able to climb stairs after 4 courses of chemotherapy. Marked improvement of LEMS was achieved by treatment for small cell lung carcinoma.
AuthorsHisae Honoki, Yukio Kawagishi, Hirofumi Oda, Toshiro Miwa, Minehiko Inomata, Tadashi Fujita, Shoko Matsui, Tatsuhiko Kashii, Muneharu Maruyama, Masashi Kobayashi
JournalNihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 41 Issue 5 Pg. 331-5 (May 2003) ISSN: 1343-3490 [Print] Japan
PMID12822423 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Etoposide
  • Carboplatin
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Carboplatin (administration & dosage)
  • Carcinoma, Small Cell (complications, drug therapy, radiotherapy)
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Etoposide (administration & dosage)
  • Humans
  • Inappropriate ADH Syndrome (complications)
  • Lambert-Eaton Myasthenic Syndrome (complications)
  • Lung Neoplasms (complications, drug therapy, radiotherapy)
  • Male

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