[Experience in the use of polyosm in the treatment of edematous maculopathy].

Abstract

The efficiency and tolerability of using a new osmotic diuretic, i.e. polyosm (a solution of polyethylene oxide 400 for the intravenous administration), was studied in patients with edematous maculopathy of different geneses. The drop-by-drop introduction of polyosm, 200 ml (the dose amounted to 0.8-1 g/kg in terms of polyethylene oxide 400), one per day and during 3 days, proved the efficiency of the preparation as a corrector of edematous maculopathy, which was confirmed by an involution of the eye-tissue edema, reduced sizes of the central scotoma, and by an improved visual acuity. The tolerability of the course-based administration of polyosm by patients was found to be good and satisfactory. No negative impact produced by the preparation on the indices of central hemodynamics was detected; the hypotensive effect of polyosm was found, as a normalized level of the systolic and diastolic pressure, only in patients with an originally high arterial pressure. Hypokalemia was, after the course-based use of polyosm, of a moderate nature.

• Authors: M B Plotnikov, O G Shilova, N Iu Khatminskiĭ, I V Zapuskalov, A A Fetisov, S V Filippova, N A Baliuk, Iu F Khatminskiĭ, M P Pronin, N F Fedorova
• Journal: Vestnik oftalmologii (Vestn Oftalmol) 2003 May-Jun Vol. 119 Issue 3 Pg. 43-5 ISSN: 0042-465X [Print] Russia (Federation)
• Vernacular Title: Opyt primeneniia poliosma dlia lecheniia otechnoĭ makulopatii.
• PMID: 12822338 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Diuretics, Osmotic
• Polyethylene Glycols

Topics

• Adult
• Aged
• Data Interpretation, Statistical
• Diuretics, Osmotic (administration & dosage, therapeutic use)
• Humans
• Injections, Intravenous
• Macula Lutea
• Middle Aged
• Polyethylene Glycols (administration & dosage, therapeutic use)
• Retinal Diseases (drug therapy)
• Visual Acuity