Abstract | UNLABELLED: The goal of our study was to evaluate the analgesic efficacy and safety of administering rofecoxib (1 mg/kg), a cyclo-oxygenase (COX)-2 selective nonsteroidal antiinflammatory drug, before pediatric tonsillectomy. Sixty-six patients, aged 3-11 yr, scheduled to undergo tonsillectomy received either placebo or rofecoxib (1 mg/kg). There were no significant differences between the two study groups with respect to demographics and blood loss. We found that the pain scores were significantly lower in the rofecoxib group compared with the control group at 2 h (P < 0.05) and 24 h (P < 0.006). The incidence of nausea (P < 0.03) and vomiting (P < 0.004) at home was more frequent in the control group than in the rofecoxib group. We conclude that a single preoperative dose of rofecoxib resulted in less vomiting and lower 24-h pain scores in pediatric patients undergoing an elective tonsillectomy. IMPLICATIONS:
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Authors | Wandana Joshi, Neil Roy Connelly, Scott S Reuben, Marten Wolckenhaar, Nikhil Thakkar |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 97
Issue 1
Pg. 35-8, table of contents
(Jul 2003)
ISSN: 0003-2999 [Print] United States |
PMID | 12818939
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Anti-Inflammatory Agents, Non-Steroidal
- Lactones
- Sulfones
- rofecoxib
- Acetaminophen
- Codeine
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Topics |
- Acetaminophen
(therapeutic use)
- Analgesics, Non-Narcotic
(therapeutic use)
- Analgesics, Opioid
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Codeine
(therapeutic use)
- Female
- Hemorrhage
(chemically induced, epidemiology)
- Humans
- Lactones
(adverse effects, therapeutic use)
- Male
- Pain Measurement
(drug effects)
- Pain, Postoperative
(drug therapy)
- Postoperative Complications
(chemically induced, epidemiology)
- Sulfones
- Tonsillectomy
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