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[Results of high-dose intravenous immunoglobulin treatment of patients with pretibial myxedema and Basedow's disease. Preliminary findings].

Abstract
Three patients affected with Graves' ophthalmopathy and pretibial myxoedema have been treated with high dose intravenous immunoglobulins. We have observed in all patients clinical improvement of pretibial myxoedema and a parallel reduction or negativization of the titre of circulating thyroglobulin, microsomal, TSH receptor autoantibodies and of non organ-specific antibodies (antinuclear, anti smooth muscle cells and antimitochondrial autoantibodies). In conclusion the results of this study suggest that intravenous immunoglobulin are effective in the treatment of pretibial myxoedema and probably act by an immunomodulation of autoimmune phenomena.
AuthorsA Antonelli, A Saracino, S Agostini, B Alberti, A Melosi, C Gambuzza, G Avantaggiato, L Baschieri
JournalLa Clinica terapeutica (Clin Ter) Vol. 141 Issue 9 Pt 2 Pg. 63-8 (Sep 1992) ISSN: 0009-9074 [Print] Italy
Vernacular TitleRisultati del trattamento con immunoglobuline endovena ad alto dosaggio in pazienti affetti da mixedema pretibiale e morbo di Basedow. Osservazioni preliminari.
PMID1281765 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Autoantibodies
  • Immunoglobulins, Intravenous
  • gamma-Globulins
Topics
  • Adult
  • Autoantibodies (blood)
  • Female
  • Graves Disease (complications, immunology, therapy)
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Leg Dermatoses (etiology, immunology, therapy)
  • Male
  • Middle Aged
  • Myxedema (etiology, immunology, therapy)
  • Treatment Outcome
  • gamma-Globulins (administration & dosage)

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