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[Alterations of Axin protein expression during cardiac remodeling in rats].

Abstract
The purpose of the present study was to observe the expression of Axin protein during cardiac remodeling in rats. Cardiac remodeling animal models were prepared with the methods of jugular venous norepinephrine (NE)-infusion or arterial-vein fistula (AVF). The ultrasonic parameters of rat hearts were recorded before sacrifice. The expressions of Axin protein were determined by Western blot in rat hearts from different remodeling models as well as cultured cardiac fibroblasts from adult rats. Cardiac concentric hypertrophy and fibrosis was induced by 3-day jugular vein infusion of NE in rats. The expression of Axin in the left ventricles increased significantly compared with that of the control group. Cardiac eccentric hypertrophy without fibrosis was induced by A-V fistula for one week in rats, and no change in Axin protein expression in the left ventricles was observed. In cultured adult rat cardiac fibroblasts, NE treatment for 24 h increased significantly the Axin protein level. It is therefore concluded that Axin protein was expressed in rat heart and increased significantly in left ventricles during NE-induced rat cardiac remodeling, which may be relevant to cardiac fibrosis.
AuthorsPing Li, Jin-Liang Li, Feng Yin, Jie Yan, Xin-Heng Feng, Zhao-Ping Li, Qi-De Han, You-Yi Zhang
JournalSheng li xue bao : [Acta physiologica Sinica] (Sheng Li Xue Bao) Vol. 55 Issue 3 Pg. 331-5 (Jun 25 2003) ISSN: 0371-0874 [Print] China
PMID12817302 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Axin Protein
  • Norepinephrine
Topics
  • Animals
  • Axin Protein (metabolism)
  • Cells, Cultured
  • Fibroblasts (cytology)
  • Heart Ventricles (metabolism)
  • Male
  • Myocytes, Cardiac (cytology)
  • Norepinephrine (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Ventricular Remodeling (physiology)

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