Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.

Abstract	Natural products comprise a major source of small molecular weight angiogenesis inhibitors. We have used the transformed endothelial cell line SVR as an effective screen of natural product extracts to isolate anti-angiogenesis and anti-tumor compounds. Aqueous extracts of Magnolia grandiflora exhibit potent activity in our SVR proliferation assays. We found that the small molecular weight compound honokiol is the active principle of magnolia extract. Honokiol exhibited potent anti-proliferative activity against SVR cells in vitro. In addition, honokiol demonstrated preferential inhibition of primary human endothelial cells compared with fibroblasts and this inhibition was antagonized by antibodies against TNF alpha-related apoptosis-inducing ligand. In vivo, honokiol was highly effective against angiosarcoma in nude mice. Our preclinical data suggests that honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent.
Authors	Xianhe Bai, Francesca Cerimele, Masuko Ushio-Fukai, Muhammad Waqas, Paul M Campbell, Baskaran Govindarajan, Channing J Der, Traci Battle, David A Frank, Keqiang Ye, Emma Murad, Wolfgang Dubiel, Gerald Soff, Jack L Arbiser
Journal	The Journal of biological chemistry (J Biol Chem) Vol. 278 Issue 37 Pg. 35501-7 (Sep 12 2003) ISSN: 0021-9258 [Print] United States
PMID	12816951 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Angiogenesis Inhibitors Biphenyl Compounds Lignans Plant Extracts honokiol
Topics	Angiogenesis Inhibitors (pharmacology, therapeutic use) Animals Apoptosis (drug effects) Biphenyl Compounds (pharmacology, therapeutic use) Cell Division (drug effects) Cell Line Cell Line, Transformed Endothelium, Vascular (drug effects, transplantation) Hemangiosarcoma (drug therapy, pathology) Humans Lignans MAP Kinase Signaling System (drug effects, physiology) Magnolia Mice Mice, Nude Phytotherapy Plant Extracts (pharmacology, therapeutic use) Transplantation, Heterologous

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