HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Stem cell transplantation for myelofibrosis: a report from two Canadian centers.

Abstract
We describe the course of 25 patients with myelofibrosis (MF) due to agnogenic myeloid metaplasia (n=19) or essential thrombocytosis (n=6) who underwent allogeneic stem cell transplantation (SCT) at one of two Canadian centers. The median age at transplantation was 48.7 (IQR 45.9-50.4) years and transplantation was carried out at a median of 10.7 (IQR 5.67-26.5) months after diagnosis. Granulocyte engraftment (absolute neutrophil count >0.5 x 109/l) occurred at a median of 20 days after transplantation for splenectomized patients, compared with 27.5 days for nonsplenectomized individuals (P=0.03). Increased risk of grade II-IV acute graft-versus-host disease (P=0.04) was noted in patients transplanted after splenectomy. Patients with MF received 0.264+/-0.189 U of packed red blood cells per day over the first 180 days after transplantation, and remained dependent on red blood cell transfusions for a median of 123 (IQR 48-205) days. Complete remission of MF was documented in 33% of evaluable patients. The 1 year cumulative nonrelapse mortality was 48.3%. Median survival for this group of patients was 393 (IQR 109-1014+) days, with a projected 2-year overall survival of 41%. We conclude that allogeneic SCT offers a reasonable chance for prolonged survival in patients with advanced MF, but this occurs at the cost of considerable toxicity and nonrelapse mortality.
AuthorsA Daly, K Song, T Nevill, S Nantel, C Toze, D Hogge, D Forrest, J Lavoie, H Sutherland, J Shepherd, W Hasegawa, J Lipton, H Messner, T Kiss
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 32 Issue 1 Pg. 35-40 (Jul 2003) ISSN: 0268-3369 [Print] England
PMID12815476 (Publication Type: Journal Article)
Topics
  • Erythrocyte Transfusion
  • Female
  • Follow-Up Studies
  • Graft Survival
  • Graft vs Host Disease (etiology)
  • Hematopoietic Stem Cell Transplantation (adverse effects, methods, mortality)
  • Hepatic Veno-Occlusive Disease (etiology)
  • Humans
  • Male
  • Middle Aged
  • Primary Myelofibrosis (complications, etiology, mortality, therapy)
  • Splenectomy
  • Survival Analysis
  • Thrombocytosis (complications)
  • Transplantation, Homologous

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: